Premium
In vivo activity of nifurzide and nifuroxazide in intestinal bacteria in man and gnotobiotic mice
Author(s) -
LEONARD FLORENCE,
ANDREMONT A.,
TANCREDE C.
Publication year - 1985
Publication title -
journal of applied bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 0021-8847
DOI - 10.1111/j.1365-2672.1985.tb01710.x
Subject(s) - microbiology and biotechnology , in vivo , bacteria , enterobacteriaceae , feces , biology , shigella , colonisation resistance , in vitro , escherichia coli , anaerobic bacteria , shigella flexneri , colonization , salmonella , biochemistry , genetics , gene
Although Gram‐negative enteropathogenic bacteria are the target strains of nifurzide and nifuroxazide treatments, neither drug affected faecal counts of in vitro ‐susceptible Enterobacteriaceae in healthy volunteers. This absence of activity was shown to be due to the poor solubility of the drugs tested. Therefore, effect of high doses of nifurzide was investigated in gnotobiotic mice. Activity against in vitro susceptible enteropathogens was then observed. Normal bacterial cells were replaced in the faeces by elongated, nonseptate and unflagellated mutants. Moreover, the resistance to colonization by enterotoxigenic Escherichia coli and Shigella flexeri of an anaerobic flora of human origin was sharply decreased.