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Towards microbiological quality assurance in radiation sterilization processing: simulation of the radiation inactivation process
Author(s) -
FITCH F.R.,
DOOLAN P.T.,
DWYER J.,
DWYER V.M.,
HALLS N.A.,
TALLENTIRE A.
Publication year - 1985
Publication title -
journal of applied bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 0021-8847
DOI - 10.1111/j.1365-2672.1985.tb01465.x
Subject(s) - bioburden , limiting , sterilization (economics) , quality assurance , radiation , population , irradiation , computer science , nuclear engineering , environmental science , process engineering , biology , medicine , microbiology and biotechnology , business , engineering , environmental health , physics , mechanical engineering , optics , pathology , nuclear physics , external quality assessment , finance , exchange rate , foreign exchange market
A method is developed for computer simulation of the inactivation of microorganisms on items by irradiation. It is shown that in a population of items subjected to increasing doses of radiation the proportion contaminated approaches the appropriate Limiting Case, outlined in a previous paper, as numbers of organisms are decreased by inactivation. The behaviour of populations of items having different proportions of ‘spikes’ (high bioburden levels) is considered.