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Effect of sulphasalazine on the human intestinal flora
Author(s) -
Hazenberg M.P.,
Barker M.,
BothPatoir H.C.,
Embden J.G.H. Ruseler van,
Schroder A.M.
Publication year - 1982
Publication title -
journal of applied bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 0021-8847
DOI - 10.1111/j.1365-2672.1982.tb04379.x
Subject(s) - flora (microbiology) , ulcerative colitis , sulfasalazine , medicine , gastroenterology , bacteria , biology , disease , genetics
Sulphasalazine is commonly used to treat patients with ulcerative colitis but the mode of action is still unexplained. To investigate a possible antibacterial effect of sulphasalazine, the faecal flora composition was studied in patients with ulcerative colitis and in mice harbouring a human intestinal flora. Patients on sulphasalazine were found to have an intestinal flora that was completely resistant to sulphapyri‐dine. Oral administration of sulphasalazine did not influence the composition of the human flora in mice.