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The isolation of a fungal metabolite which exhibits antimicrobial synergy with sterigmatocystin
Author(s) -
Perry M.J.,
Adlard M.W.,
Holt G.
Publication year - 1982
Publication title -
journal of applied bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 0021-8847
DOI - 10.1111/j.1365-2672.1982.tb04376.x
Subject(s) - sterigmatocystin , aflatoxin , metabolite , antimicrobial , microbiology and biotechnology , aspergillus , biology , chemistry , aspergillus versicolor , aspergillus nidulans , secondary metabolite , biochemistry , food science , gene , mutant
A metabolite, which acted synergistically with sterigmatocystin to inhibit the growth of several Gram positive bacteria, has been isolated from several strains of Aspergillus nidulans. Preliminary characterization of this metabolite indicated that it was a high‐molecular‐weight glycoprotein. Dihydrosterigmatocystin, aflatoxin B, and aflatoxin G t all failed to exhibit antimicrobial synergy with the glycoprotein. Thus, the synergy with the glycoprotein was specific for sterigmatocystin and the presence of the unsaturated bifuran moiety was shown to be essential to the antimicrobial action of the synergy.