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Liposome‐trapped Penicillins in Growth Inhibition of Some Penicillin‐resistant Bacteria
Author(s) -
CHOWDHURY M. K. R.,
GOSWAMI R.,
CHAKRABARTI P.
Publication year - 1981
Publication title -
journal of applied bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 0021-8847
DOI - 10.1111/j.1365-2672.1981.tb01236.x
Subject(s) - liposome , penicillin , bacillus licheniformis , staphylococcus aureus , microbiology and biotechnology , escherichia coli , growth inhibition , chemistry , bacteria , antibiotics , biology , biochemistry , bacillus subtilis , in vitro , genetics , gene
Liposome‐trapped penicillin causes growth inhibition of penicillin‐resistant Staphylococcus aureus (meta 18), Bacillus licheniformis (749/C) and Escherichia coli. Liposome has been prepared from the positively charged, negatively charged and polar lipids of respective organisms. Positively charged liposome containing penicillin causes 77% growth inhibition in the case of Staph. aureus (meta 18) and 61% in the case of Esch. coli. In the case of B. licheniformis (749/C), 40–43% growth inhibition has been observed with liposome‐entrapped penicillin. Homology, composition and charge of liposomes do not seem to have significant effect in percentage inhibition of this organism.