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Antibacterial Activity of a New Cephalosporin, Cefotaxime
Author(s) -
RUSSELL A. D.,
ROGERS D. T.
Publication year - 1980
Publication title -
journal of applied bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 0021-8847
DOI - 10.1111/j.1365-2672.1980.tb01051.x
Subject(s) - cefotaxime , cefoxitin , serratia marcescens , cephalosporin , cephaloridine , cefuroxime , microbiology and biotechnology , antibiotics , antibacterial activity , chemistry , pseudomonas aeruginosa , bacteria , cefamandole , biology , escherichia coli , biochemistry , staphylococcus aureus , genetics , gene
The antibacterial activity of a new cephalosporin derivative, cefotaxime (HR 756), was determined. The antibiotic was active at low concentrations against R + and R ‐ strains of Gram negative bacteria, including two out of three strains of Serratia marcescens. In general higher concentrations were needed to inhibit growth of Pseudomonas aeruginosa. Low concentrations induced elongation of cells in circumstances conducive to active growth; higher concentrations caused lysis in some strains. Cefotaxime was more stable than cephaloridine, cephalothin, cephalexin, cefoxitin and cefuroxime to various β‐lactamases.