Premium
Hydroxylations of Biphenyl by Fungi
Author(s) -
SMITH R. V.,
DAVIS P. J.,
CLARK A. M.,
GLOVERMILTON S.
Publication year - 1980
Publication title -
journal of applied bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 0021-8847
DOI - 10.1111/j.1365-2672.1980.tb01044.x
Subject(s) - biphenyl , chemistry , metabolite , substrate (aquarium) , phenols , yield (engineering) , organic chemistry , polychlorinated biphenyl , chromatography , aspergillus , aspergillus parasiticus , mycotoxin , biochemistry , biology , botany , food science , materials science , ecology , metallurgy
Sixty‐six species of fungi were screened for their ability to hydroxylate biphenyl. Thin‐layer and gas chromatographic analyses indicated that seven organisms actively hydroxylated this substrate. Of particular interest were Cunninghamella echinulata ATCC 9244 which produced 4‐hydroxybiphenyl as the major metabolite, Helicostylum piriforme QM 6945 which produced exclusively 2‐hydroxybiphehyl, and Aspergillus parasiticus ATCC 15517 which produced a good yield of 4, 4′‐dihydroxybiphenyl. These results were confirmed by isolation of the phenolic metabolites following preparative‐scale conversions and comparisons of the isolated phenols with authentic reference materials.