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The Anti‐Endotoxin Activity of Taurolin in Experimental Animals
Author(s) -
PFIRRMANN R. W.,
LESLIE G. B.
Publication year - 1979
Publication title -
journal of applied bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 0021-8847
DOI - 10.1111/j.1365-2672.1979.tb02586.x
Subject(s) - bacteroides fragilis , escherichia coli , microbiology and biotechnology , broad spectrum , lipopolysaccharide , bacteroides , biology , escherichia , chemistry , bacteria , immunology , antibiotics , biochemistry , combinatorial chemistry , genetics , gene
Taurolin, a broad spectrum bactericidal agent, protected experimental animals from the lethal effects of Escherichia coli and Bacteroides fragilis endotoxin. Taurolin also prevented the pyrexic response of rabbits to TAB vaccine. Results suggest that Taurolin exerts its antiendotoxic effect by direct reaction with the endotoxin molecule.