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Synergism between Chlorhexidine and Polymyxins against Pseudomonas aeruginosa
Author(s) -
ALNAJJAR A. R.,
QUESNEL L. B.
Publication year - 1979
Publication title -
journal of applied bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 0021-8847
DOI - 10.1111/j.1365-2672.1979.tb01208.x
Subject(s) - polymyxin , pseudomonas aeruginosa , chlorhexidine , polymyxin b , microbiology and biotechnology , chemistry , bacteria , biology , medicine , antibiotics , dentistry , genetics
Chlorhexidine acts synergistically with the polymyxins B and E causing increased and rapid release of cell contents from Pseudomonas aeruginosa. While the polymyxin target molecule is phospholipid, evidence is provided for the proposal that the primary target for Chlorhexidine action is a protein component of the cytoplasmic membrane.