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The Production of Antisera to the Klebsiella Capsular Antigens
Author(s) -
EDMONDSON A. S.,
COOKE E. MARY
Publication year - 1979
Publication title -
journal of applied bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 0021-8847
DOI - 10.1111/j.1365-2672.1979.tb00858.x
Subject(s) - antiserum , homologous chromosome , microbiology and biotechnology , cross reactions , antigen , immune sera , klebsiella , biology , chemistry , virology , escherichia coli , immunology , biochemistry , gene
Three methods of antiserum production have been compared. One of these consistently gave rise to greater homologous quellung titres and was used routinely. A modification of this method using vaccines consisting of washed, killed suspensions of type strains resulted in no significant increase in titres or decrease in cross‐reactions. Considerable differences were found between the homologous quellung titres and cross‐reactions of antisera prepared in the same laboratory on different occasions.