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Synergism between Chlorhexidine and Sulphadiazine
Author(s) -
QUESNEL L. B.,
ALNAJJAR A. R.,
BUDDHAVUDHIKRAI P.
Publication year - 1978
Publication title -
journal of applied bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 0021-8847
DOI - 10.1111/j.1365-2672.1978.tb04241.x
Subject(s) - chlorhexidine , proteus , chemistry , pseudomonas aeruginosa , microbiology and biotechnology , sulfadiazine , staphylococcus aureus , staphylococcus , bacteria , antibiotics , biochemistry , escherichia coli , biology , medicine , dentistry , genetics , gene
Chlorhexidine and sulphadiazine react synergistically against strains of Pseudomonas. Proteus and Staphylococcus , with high factors of synergy. The impermeability of these strains to sulphadiazine is destroyed by low concentrations of chlorhexidine, permitting the accumulation of sulphadiazine which then inhibits protein synthesis. The combination of these drugs is bactericidal.