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Large‐scale Harvesting and Concentration of Bacteria by Tangential Flow Filtration
Author(s) -
REID D. E.,
ADLAM C.
Publication year - 1976
Publication title -
journal of applied bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 0021-8847
DOI - 10.1111/j.1365-2672.1976.tb00637.x
Subject(s) - filtration (mathematics) , bacteria , filter (signal processing) , pulp and paper industry , cross flow filtration , flow (mathematics) , chromatography , chemistry , environmental science , microbiology and biotechnology , biology , mathematics , biochemistry , computer science , membrane , engineering , statistics , genetics , geometry , computer vision
1 A self‐contained tangential flow filtration system was used to harvest, concentrate and wash suspensions of corynebacteria aseptically. 2 Using two filter stacks each containing 15 × 0.6 nm filters, 60 l of culture could be concentrated to 8 l, thrice washed and harvested within a working day. 3 Organism washing was efficient and no impairment of activity of harvested organisms was seen. 4 Tangential flow filtration provides a simple rapid method for harvesting bacteria and their extracellular products aseptically from cultures grown on a production scale.