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Antibacterial Activity of Ambodryl and Benadryl
Author(s) -
DASTIDAR SUJATA G.,
SAHA P. K.,
SANYAMAT B.,
CHAKRABARTY A. N.
Publication year - 1976
Publication title -
journal of applied bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 0021-8847
DOI - 10.1111/j.1365-2672.1976.tb00621.x
Subject(s) - in vivo , in vitro , diphenhydramine hydrochloride , antibacterial activity , diphenhydramine , microbiology and biotechnology , pharmacology , bacteria , salmonella , spleen , virulence , chemistry , gram positive bacteria , antibiotics , biology , histamine , biochemistry , immunology , genetics , gene
Of nine antihistamines screened for in vitro antibacterial activity, ambodryl (bromodiphenhydramine hydrochloride) and benadryl (diphenhydramine hydrochloride) were the most active. At 50 to 100 μ/ml concentrations these inhibited a large number of Gram negative and Gram positive bacteria in vitro , with ambodryl having a broader spectrum. In vivo tests showed that the compounds at single doses of 3 and 1.5 μg/g body weight protected mice against a challenge with a virulent strain (LD 50 ) of Salmonella typhimurium , and also significantly reduced the multiplication of this organism in the liver, spleen and blood of the protected animals in comparison with the unprotected controls.