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Antibacterial Activity of 3‐(l‐Methyl‐5‐Nitro‐2‐Imidazolylmethylideneamino)‐2‐Oxazolidinone
Author(s) -
FROST BETTINA M.,
VALIANT M. E.,
DULANEY E. L.
Publication year - 1975
Publication title -
journal of applied bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 0021-8847
DOI - 10.1111/j.1365-2672.1975.tb00518.x
Subject(s) - furazolidone , nitrofuran , nitroimidazole , nitrofurantoin , in vivo , pharmacology , chemistry , antibacterial activity , antibiotics , oral administration , kidney , urinary system , microbiology and biotechnology , medicine , biology , bacteria , ciprofloxacin , biochemistry , organic chemistry , genetics
The nitroimidazole tested is structurally related to furazolidone in that it contains a 5‐nitro‐imidazole instead of 5‐nitrofuran. The nitroimidazole was much less active in vitro than furazolidone against a spectrum of pathogenic organisms. However, it is active in vivo by oral administration against bacterial infections of mice and its low acute toxicity gives better therapeutic indices than are obtained with furazolidone. Plasma concentrations rise rapidly following oral administration of the nitroimidazole. Sufficient urinary excretion occurred to give significant activity in a mouse kidney infection incited by Staphylococcus aureus in which nitrofurantoin was inactive.