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The Immunopurification of Tetanus Toxoid
Author(s) -
Hughes M.,
Thomson R. O.,
Knight P.,
Stephen J.
Publication year - 1974
Publication title -
journal of applied bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 0021-8847
DOI - 10.1111/j.1365-2672.1974.tb00485.x
Subject(s) - toxoid , tetanus , tetanus antitoxin , antitoxin , medicine , chemistry , virology , toxin , vaccination , biochemistry
S ummary . The isolation of tetanus toxoid by immunosorption chromatography is described. The immunosorbent, a polymerized horse antitoxin, was used repeatedly with little loss in capacity and recoveries of toxoid of > 90% were achieved. In terms of specific antigenic activity, immunopurified tetanus toxoid is purer than that purified by conventional procedures and is at least as immunogenic.