Studies on the Mode of Action of Some Cephalosporin Derivatives | Zendy

Fountain R. H. | Zendy; Russell A. D. | Zendy

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Studies on the Mode of Action of Some Cephalosporin Derivatives

Author(s) -

Fountain R. H.,

Russell A. D.

Publication year - 1969

Publication title -

journal of applied bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.889

H-Index - 156

eISSN - 1365-2672

pISSN - 0021-8847

DOI - 10.1111/j.1365-2672.1969.tb00978.x

Subject(s) - spheroplast , cephaloridine , cephalosporin , bacillus megaterium , benzylpenicillin , chemistry , escherichia coli , cephalosporin c , protoplast , microbiology and biotechnology , biochemistry , biology , bacteria , antibiotics , penicillin , genetics , gene

Summary 7‐(s‐benzylthioacetamido)‐cephem‐3‐ylmethyl‐ N ‐dimethyldithiocarbamate‐4‐carboxylic acid (cephalosporin 7/30) prevented benzylpenicillin from inducing spheroplasts in Escherichia coli , and inhibited growth of preformed spheroplasts. These effects were also noted with dimethyldithiocarbamate (DMDT), the side‐chain at position 3 in 7/30. Cephalosporin 7/30 inhibited growth of protoplasts of Bacillus megaterium and Streptococcus faecalis . At high concentrations, 7‐[(2‐thienyl)acetamido]‐cephem‐3‐ylmethyl‐ N ‐dimethyldithiocarbamate‐ 4‐carboxylic acid (cephalosporin 87/30), with the same side‐chain at 7 as cephaloridine but with DMDT at position 3, prevented spheroplast formation in E. coli , and inhibited the growth of preformed spheroplasts. However, at lower concentrations, 87/30 induced spherical forms in E. coli . The other cephalosporins, tested induced spheroplasts in E. coli and had no effect on protoplasts.

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