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The Antibiotic Tolerance of Vibrio cholerae
Author(s) -
Naha P. M.
Publication year - 1963
Publication title -
journal of applied bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 0021-8847
DOI - 10.1111/j.1365-2672.1963.tb01147.x
Subject(s) - chlortetracycline , antibiotics , dihydrostreptomycin , penicillin , microbiology and biotechnology , vibrio cholerae , chloramphenicol , biology , streptomycin , bacteria , genetics
Summary Penicillin G, dihydrostreptomycin, chloramphenicol and chlortetracycline inhibited the growth of a strain of Vibrio cholerae in vitro , in that order of increasing effectiveness, except that at low concentrations dihydrostreptomycin was less effective than penicillin G. The amount of growth made in the presence of an antibiotic, relative to that in an antibiotic free control, as judged turbidimetrically, was a linear function of the concentration and the slopes of the regression lines differed significantly. Strains resistant to each of the four antibiotics were developed. The culture resistant to chlortetracycline was also relatively resistant to the other three antibiotics, but those which resisted the other antibiotics were greatly affected by chlortetracycline. The relationships between relative growth and concentration were not, however, obviously linear.