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THE THERAPEUTIC INDEX OF CHEMOTHERAPEUTIC AGENTS: THE EFFECT OF NUCLEIC ACID ON DIMIDIUM BROMIDE
Author(s) -
SEAMAN A.,
WOODBINE M.
Publication year - 1955
Publication title -
journal of applied bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 0021-8847
DOI - 10.1111/j.1365-2672.1955.tb02095.x
Subject(s) - nucleic acid , bromide , therapeutic index , chemistry , antibacterial activity , pharmacology , toxicity , combinatorial chemistry , biochemistry , bacteria , organic chemistry , drug , biology , genetics
SUMMARY: The complexes of dimidium bromide with nucleic acids are less toxic and bactericidal than dimidium bromide itself, but the toxicity is reduced more than the antibacterial activity. The therapeutic activity is, therefore, raised.