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A FACTORIAL INVESTIGATION OF SOME TEST CONDITIONS IN THE EVALUATION OF THE DISINFECTANT PROPERTIES OF QUATERNARY AMMONIUM COMPOUNDS USING A DRIED FILM OF BACTERIUM COLI TYPE I
Author(s) -
CLARKE PAMELA M.,
GARVIE ELLEN I.
Publication year - 1955
Publication title -
journal of applied bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 0021-8847
DOI - 10.1111/j.1365-2672.1955.tb02066.x
Subject(s) - disinfectant , ammonium , bromide , ammonium bromide , chemistry , ammonium chloride , bacteria , factorial experiment , nuclear chemistry , suspension (topology) , chloride , chromatography , pulmonary surfactant , inorganic chemistry , organic chemistry , biochemistry , biology , homotopy , pure mathematics , genetics , statistics , mathematics
SUMMARY: In a series of experiments in which a suspension of Bacterium coli strain 28.D.10, dried on a metal surface, was treated with alkyldimethylbenzylammonium chloride (BC) and cetyltrimethylammonium bromide (CTAB), the variability of the results compared favourably with that observed by other workers in the same field of disinfection, but using different methods. Quantitative estimates were obtained for the effects and interactions, on the bactericidal activity of the quaternary ammonium compound, of time and temperature of exposure, and of concentration of the compound. Increases in each of these factors reduced the percentage of surviving organisms. CTAB was less active than BC. Changes in pH between 5 and 9 did not affect the estimated activity of BC or CTAB, but in the presence either of phosphate or of borate buffers the bactericidal activity of both compounds was decreased.