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LABORATORY EVALUATION OF ANTIBACTERIAL SEMISOLID PHARMACEUTICALS
Author(s) -
WALTERS A. H.,
COUSINS CHRISTINA M.
Publication year - 1955
Publication title -
journal of applied bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 0021-8847
DOI - 10.1111/j.1365-2672.1955.tb02059.x
Subject(s) - disinfectant , potency , antibacterial activity , chemistry , microbiology and biotechnology , chromatography , biology , bacteria , in vitro , organic chemistry , biochemistry , genetics
SUMMARY: The laboratory evaluation of the disinfectant function of antibacterial semisolid pharmaceuticals (A.S.Ps.) by zone tests and a direct mixing time (D.M.T.) test is described. The factors which can influence the results of these tests are discussed. Zone tests applied to an A.S.P. may not indicate the degree of antibacterial potency; absence of growth inhibition zones does not necessarily mean no specific disinfectant function. Using similar A.S.Ps., zone tests were compared with D.M.T. tests; it is shown that parallel findings may not always be obtained. However, such tests usually provide a useful form of microbiological assay of the specific disinfectant function of an A.S.P. which can assist chemists in preparing new formulations. (Techniques for bacteriological evaluations of A.S.Ps. in actual practice are not included).