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Variant Carvajal syndrome with additional dental anomalies
Author(s) -
BARBER SOPHY,
DAY PETER,
JUDGE MARY,
TOOLE EDELL O’,
FAYLE STEPHEN
Publication year - 2012
Publication title -
international journal of paediatric dentistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.183
H-Index - 62
eISSN - 1365-263X
pISSN - 0960-7439
DOI - 10.1111/j.1365-263x.2012.01230.x
Subject(s) - medicine , dermatology , keratoderma , palmoplantar keratoderma , girl , sudden death , nail (fastener) , dental anomalies , periodontitis , dermatomyositis , dentistry , hyperkeratosis , genetics , materials science , metallurgy , biology
International Journal of Paediatric Dentistry 2012; 22: 390–396 Background This paper aims to review the case of a girl who presented with a number of dental anomalies, in addition to unusual skin, nail and hair conditions. Tragically an undiagnosed cardiomyopathy caused unexpected sudden death. The case is discussed with reference to a number of dermatological and oral conditions which were considered as possible diagnoses. Case Report AW had been under long term dental care for prepubertal periodontitis, premature root resorption of primary teeth, soft tissue and dental anomalies, and angular cheilitis. Separately she had also been seen by several dermatologists with respect to palmar plantar keratosis, striae keratoderma, wiry hair and abnormal finger nails. Tragically the patient suffered a sudden unexpected death and the subsequent post mortem identified an undiagnosed dilated cardiomyopathy. Conclusion The most likely diagnosis is that this case is a variant of Carvajal Syndrome with additional dental anomalies. To date we have been unable to identify mutations in the desoplakin gene. We aim to emphasise the importance of recognising these dental and dermatological signs when they present together as a potential risk factor for cardiac abnormalities.