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Proinflammatory cytokines during the initial phase of oral mucositis in patients with acute lymphoblastic leukaemia
Author(s) -
MORALESROJAS THAIS,
VIERA NINOSKA,
MORÓNMEDINA ALEJANDRA,
ÁLVAREZ CARMEN JULIA,
ÁLVAREZ ALEJANDRA
Publication year - 2012
Publication title -
international journal of paediatric dentistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.183
H-Index - 62
eISSN - 1365-263X
pISSN - 0960-7439
DOI - 10.1111/j.1365-263x.2011.01175.x
Subject(s) - medicine , proinflammatory cytokine , mucositis , saliva , methotrexate , cytokine , lymphoblastic leukemia , immunology , gastroenterology , leukemia , chemotherapy , inflammation
International Journal of Paediatric Dentistry 2012; 22: 191–196 Objective. The aim of the study was to compare the production of proinflammatory cytokines during the initial phase of mucositis in patients with acute lymphoblastic leukaemia. Methods. A randomized, controlled clinical trial was carried out. Cytokine levels were determined in blood and saliva using ELISA, three times after the administration of methotrexate and only once in the control group. Results. Comparison of the results showed significant differences for IL‐6 and TNF‐α in blood and IL‐6 in saliva. Conclusion. It would seem that 96 h is an ideal time for determining the parameters evaluated both in blood and in saliva.