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Prunus mume extract exhibits antimicrobial activity against pathogenic oral bacteria
Author(s) -
SENEVIRATNE CHAMIDA J.,
WONG RICKY W. K.,
HÄGG URBAN,
CHEN YONG,
HERATH THANUJA D. K.,
LAKSHMAN SAMARANAYAKE P.,
KAO RICHARD
Publication year - 2011
Publication title -
international journal of paediatric dentistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.183
H-Index - 62
eISSN - 1365-263X
pISSN - 0960-7439
DOI - 10.1111/j.1365-263x.2011.01123.x
Subject(s) - medicine , antimicrobial , prunus , pathogenic bacteria , bacteria , traditional medicine , microbiology and biotechnology , biology , genetics , botany
International Journal of Paediatric Dentistry 2011; 21: 299–305Objectives. Prunus mume is a common fruit in Asia, which has been used in traditional Chinese medicine. In this study, we focused on the antimicrobial properties of Prunus mume extract against oral pathogens related to dental caries and periodontal diseases. Study design. A total of 15 oral pathogens including Streptococcus mutans , S. sobrinus , S. mitis , S. sanguinis , Lactobacillus acidophilus , P. gingivalis , Aggregatibacter actinomycetemcomitans , and Candida species were included in the study. Initially, agar diffusion assay was performed to screen the antimicrobial activities of Prunus mume extract. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were then determined for sensitive species. Effect of Prunus mume extract on human oral keratinocytes (HOK) viability was also tested. Result. In the agar diffusion assay, drug suspension of 2 g/mL was able to inhibit all the bacterial species tested, but not the fungal species. MIC and MBC range of Prunus mume extract against the oral bacteria was 0.15625–0.0003 g/mL and P. gingivalis being the most susceptible species. Prune extract did not cause any detrimental effect on HOK. Conclusion. Prunus mume extract may be a potential candidate for developing an oral antimicrobial agent to control or prevent dental diseases associated with oral pathogenic bacteria.