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Recurrent aphthous ulcers in Fanconi's anaemia: a case report
Author(s) -
Otan Feyza,
Açikgöz Gokhan,
Sakallioǧlu Umur,
Özkan Burcu
Publication year - 2004
Publication title -
international journal of paediatric dentistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.183
H-Index - 62
eISSN - 1365-263X
pISSN - 0960-7439
DOI - 10.1111/j.1365-263x.2004.00549.x
Subject(s) - medicine , neutropenia , dermatology , fanconi anemia , pediatrics , surgery , gastroenterology , chemotherapy , biochemistry , chemistry , dna repair , gene
Summary. Fanconi's anaemia (FA) is an autosomal recessive disorder that is clinically characterized by aplastic anaemia, congenital malformations of the renal, cardiac, skeletal and skin structures, and an increased predisposition to malignancies. Patients with FA often present with bleeding and infection, which are symptoms related to thrombocytopenia and neutropenia. There are few reports of the oral manifestations of FA. We describe oral aphthous ulcerations in two siblings with FA. There was a rapid improvement and healing of ulcers after blood transfusions and increased haemoglobin levels. This may support the role of severe anaemia in oral ulcerations.