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Chemopreventive Potential of Wild Lowbush Blueberry Fruits in Multiple Stages of Carcinogenesis
Author(s) -
Kraft Tristan F. Burns,
Schmidt Barbara M.,
Yousef G.G.,
Knight Christopher T.G.,
Cuendet Muriel,
Kang YoungHwa,
Pezzuto John M.,
Seigler David S.,
Lila Mary Ann
Publication year - 2005
Publication title -
journal of food science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 150
eISSN - 1750-3841
pISSN - 0022-1147
DOI - 10.1111/j.1365-2621.2005.tb07151.x
Subject(s) - chemistry , ornithine decarboxylase , proanthocyanidin , anticarcinogen , carcinogenesis , biochemistry , tumor promotion , bioassay , food science , antioxidant , polyphenol , enzyme , biology , genetics , gene
Wild lowbush blueberry fruit extract was fractionated using vacuum chromatography and analyzed for chemopreventive potential using bioassays that test the ability of compounds to inhibit the initiation, promotion, and progression stages of carcinogenesis. A fraction containing phytosterols was active against the initiation stage (quinone reductase assay). However, more polar compounds were inhibitors of later stages of carcinogenesis; a fraction containing flavan‐3‐ols and fractions containing mainly anthocyanins, phenolic acids, flavan‐3‐ols, and some proanthocyanidin dimers demonstrated activity against the promotion stage (cyclooxygenase and ornithine decarboxylase assays, respectively), and a proanthocyanidin‐rich fraction demonstrated antiproliferation activity (inhibition of cancerous murine hepatocyte proliferation is associated with the progression stage). These results indicate that lowbush blueberries contain a range of compounds that have bioactivity against multiple stages of carcinogenesis, and different types of phenolic compounds are active at different stages.