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Antimutagenic Activity of Sakuranetin from Prunus Jamasakura
Author(s) -
Miyazawa M.,
Kinoshita H.,
Okuno Y.
Publication year - 2003
Publication title -
journal of food science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 150
eISSN - 1750-3841
pISSN - 0022-1147
DOI - 10.1111/j.1365-2621.2003.tb14113.x
Subject(s) - chemistry , mutagen , ames test , salmonella , strain (injury) , antimutagen , gene , biochemistry , biology , bacteria , carcinogen , genetics , anatomy
ABSTRACT: Sakuranetin (compound 1) from bark of Prunus jamasakura showed a suppressive effect on umu gene expression of SOS response in Salmonella typhimurium TA1535/pSK1002 against the mutagen furylfuramide. Gene expression was suppressed 83% at a concentration of 0.70 μmol/mL. The ID50 value of compound 1 was 0.30 μmol/mL. This compound showed the suppression of 4NQO, MNNG, Trp‐P‐1, AfB1, activated Trp‐P‐1, and UV irradiation‐induced SOS response. The methylated derivative (compound 2) of compound 1 showed less suppressive effect against all mutagens than compound 1. The antimutagenic activities of compounds 1 and 2 against furylfuramide, Trp‐P‐1, and activated Trp‐P‐1 were assayed by the Ames test using the S. typhimurium TA100 strain.