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Aspartame Degradation in Solutions at Various pH Conditions
Author(s) -
Pattanaargson S.,
Chuapradit C.,
Srisukphonraruk S.
Publication year - 2001
Publication title -
journal of food science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 150
eISSN - 1750-3841
pISSN - 0022-1147
DOI - 10.1111/j.1365-2621.2001.tb15177.x
Subject(s) - aspartame , degradation (telecommunications) , chemistry , phenylalanine , high performance liquid chromatography , chromatography , acetic acid , phosphate , citric acid , hydrolysis , phosphate buffered saline , organic chemistry , amino acid , food science , biochemistry , telecommunications , computer science
This study of aspartame degradation in phosphate‐citrate buffer solutions of pH2,4,6, 7,8,10, and 12 using reverse‐phase high‐performance liquid chromatography (HPLC) showed different major degradation products for different pH ranges. The major degradation product found at pH 2 to 6 was L‐phenylalanine methyl ester (PME). The major degradation product found at pH 7 to 10 was 3,6‐dioxo‐5‐phenylmethylpiperazine acetic acid (diketopiperazine, DKP). L‐aspartyl‐phenylalanine (Asp‐Phe) was the major product detected at pH 12.