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Inhibition of Oxidative and Antioxidative Enzymes by Trans‐Resveratrol
Author(s) -
Fan X.,
Mattheis J.P.
Publication year - 2001
Publication title -
journal of food science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 150
eISSN - 1750-3841
pISSN - 0022-1147
DOI - 10.1111/j.1365-2621.2001.tb11316.x
Subject(s) - chemistry , resveratrol , salicylhydroxamic acid , biochemistry , catalase , lipoxygenase , peroxidase , superoxide dismutase , enzyme , nordihydroguaiaretic acid , oxidative phosphorylation , phytoalexin , oxidative enzyme
Trans‐resveratrol, a phytoalexin produced by a variety of plants, has been shown to inhibit oxidative enzymes in an animal cell system. Its effect on several oxidative and antioxidative enzymes from plants was investigated using in vitro assays. Trans‐resveratrol inhibited superoxide dismutase, lipoxygenase, catalase, peroxidase, polyphenol oxidase, and 1‐aminocyclopropane‐1‐carboxylic acid oxidase with apparent K I 's of 10, 90, 100, 255, 305, and 350 μM, respectively. Trans‐resveratrol inhibited lipoxygenase activity more effectively than other lipoxygenase inhibitors, including propyl gallate, ibuprofen, ursolic acid, acetylsalicylic acid, and salicylhydroxamic acid.