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Dietary Flavonoids as Potential Natural Biological Response Modifiers Affecting the Autoimmune System
Author(s) -
NAKAGAMI TATSUYOSHI,
NANAUMITAMURA NORIKO,
TOYOMURA KOHJI,
NAKAMURA TAKESHI,
SHIGEHISA TAMOTSU
Publication year - 1995
Publication title -
journal of food science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 150
eISSN - 1750-3841
pISSN - 0022-1147
DOI - 10.1111/j.1365-2621.1995.tb06199.x
Subject(s) - complement system , myricetin , chemistry , classical complement pathway , in vitro , biological activity , complement (music) , biochemistry , immune system , epigallocatechin gallate , flavonoid , polyphenol , immunology , biology , antioxidant , kaempferol , phenotype , complementation , gene
In vitro anti‐complement activity of 19 phenolic compounds was evaluated in the classical pathway. Two flavonoids, epigallocatechin gallate and myricetin, exhibited marked anti‐complement activities with IC 50 values of 4.2 and 5.2 μg/mL (concentration causing 50% inhibition of complement activity), respectively. The two flavonoids appeared to interact with both antibody‐sensitized erythrocytes and complement components to inhibit the cascade reactions in the classical pathway of the complement system. The flavonoids may function as natural biological response modifiers by multiple mechanisms including anticomplement effects. Dietary flavonoids may thus affect the body's autoimmune system.