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Lack of Vitamin B6 Activity of 6‐Hydroxypyridoxine
Author(s) -
III J.F. GREGORY,
LEATHAM K.
Publication year - 1990
Publication title -
journal of food science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 150
eISSN - 1750-3841
pISSN - 0022-1147
DOI - 10.1111/j.1365-2621.1990.tb01618.x
Subject(s) - pyridoxine , vitamin b6 , vitamin , bioassay , chemistry , hydroxylation , biochemistry , food science , biology , enzyme , ecology
Hydroxylation of the C‐6 position of pyridoxine has been described recently as a mechanism for the degradation of vitamin B6 in foods. The nutritional properties of the resulting 6‐hydroxypyridoxine in mammals have not been previously evaluated. 6‐Hydroxypyridoxine was synthesized and its structure confirmed by UV and NMR spectroscopy. A rat bioassay with multiple dose levels was conducted to compare the vitamin B6 activity of pyridoxine and 6‐hydroxypyridoxine with respect to a variety of indices of vitamin B6 metabolism. By all criteria employed, 6‐hydroxypyridoxine exhibited neither vitamin B6 nor antivitamin B6 activity and, thus, is nutritionally inert.