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Influence of Selenium‐Supplemented Torula Yeast Diets on Liver‐Mediated Mutagenicity of Aflatoxin B 1
Author(s) -
HUGHES D. A.,
BJELDANES L. F.
Publication year - 1983
Publication title -
journal of food science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 150
eISSN - 1750-3841
pISSN - 0022-1147
DOI - 10.1111/j.1365-2621.1983.tb14892.x
Subject(s) - aflatoxin , phenobarbital , selenium , chemistry , body weight , food science , yeast , salmonella , biology , biochemistry , endocrinology , bacteria , genetics , organic chemistry
To determine the effect of dietary selenium on the mutagenicity of aflatoxin B 1 (AFB 1 ), male Sprague‐Dawley rats were fed rat chow or Torula yeast diets supplemented with 0.0, 0.1, 0.5, 1.0, and 5.0 ppm Se as Na 2 SeO 3 , and the 9000 × g liver supernatants were used in Salmonella /microsome mutagenesis assays. The rats were fed on the diets for 4 wk and, prior to killing, half the rats in each group received 80 mg phenobarbital/kg body weight in their drinking water for four consecutive days. Phenobarbital administration tended to increase the mutagenicity of AFB 1 in all dietary treatment groups. This increase was significant only in the chow‐fed groups, however. Addition of selenium to the basal diet produced no significant effect on liver‐mediated mutagenicity. The liver preparation from chow‐fed animals which had received phenobarbital produced the highest mutagenicity of the samples tested.