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Regulation of Aflatoxin Biosynthesis: Effect of Exogenously Supplied Cyclic Nucleotides
Author(s) -
TICE G.,
BUCHANAN R. L.
Publication year - 1982
Publication title -
journal of food science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 150
eISSN - 1750-3841
pISSN - 0022-1147
DOI - 10.1111/j.1365-2621.1982.tb11047.x
Subject(s) - aflatoxin , aspergillus parasiticus , biosynthesis , cyclic nucleotide , nucleotide , mycotoxin , stimulation , biochemistry , aspergillus , chemistry , biology , food science , microbiology and biotechnology , gene , endocrinology
The effects of CAMP, cGMP, AMP, and GMP on aflatoxin accumulation were studied using flask and test tube cultures of Aspergillus parasiticus. The response to cGMP supplementation was variable, depending on the type of culture system employed. Cyclic AMP produced a dose‐related increase in aflatoxin production, with 5.0 mM supplementation resulting in as much as an 18‐fold increase in toxin accumulation. Stimulation of aflatoxin production by cAMP was not attributable to nutritional effects, and the results suggest that cAMP may be a key regulatory control point governing aflatoxin biosynthesis.