Premium
Clastogenic and Mutagenic Activities of Maillard Reaction Model Systems
Author(s) -
POWRIE WILLIAM D.,
WU CHIU H.,
ROSIN MIRIAM P.,
STICH HANS F.
Publication year - 1981
Publication title -
journal of food science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 150
eISSN - 1750-3841
pISSN - 0022-1147
DOI - 10.1111/j.1365-2621.1981.tb04192.x
Subject(s) - maillard reaction , mutagen , clastogen , chinese hamster ovary cell , chemistry , auxotrophy , biochemistry , histidine , saccharomyces cerevisiae , carcinogen , organic chemistry , amino acid , genotoxicity , yeast , escherichia coli , toxicity , gene , receptor
Three short‐term bioassays were employed to assess the clastogenic and mutagenic activities of Maillard reaction sugar‐amino acid solutions at initial pH values of 7 and 10. All of the Maillard reaction solutions with no S9 activation induced significant increases in chromosome aberrations in Chinese hamster ovary (CHO) cells. Mitotic recombination and mutation occurred in Saccharomyces cerevisiae strain D5 cells when exposed to all Maillard reaction solutions. When Salmonella typhimurium TA100 cells were treated with Maillard reaction compounds, induction of revertants to histidine prototrophy occurred. Mutagen concentration in the browning reaction solution was dependent on initial pH.