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BUTYLATED HYDROXYANISOLE (BHA) INDUCED CHANGES IN THE SYNTHESIS OF POLAR LIPIDS AND IN THE MOLAR RATIO OF TETRAHYMANOL TO POLAR LIPIDS IN TETRAHYMENA PYRIFORMIS
Author(s) -
SURAK J. G.,
SINGH R. G.
Publication year - 1980
Publication title -
journal of food science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 150
eISSN - 1750-3841
pISSN - 0022-1147
DOI - 10.1111/j.1365-2621.1980.tb06531.x
Subject(s) - butylated hydroxyanisole , tetrahymena pyriformis , phosphatidylethanolamine , chemistry , tetrahymena , polar , biochemistry , molar ratio , molar , lysophosphatidylcholine , lipophilicity , phospholipid , organic chemistry , phosphatidylcholine , antioxidant , biology , physics , astronomy , membrane , catalysis , paleontology
When butylated hydroxyanisole (BHA) was added to cultures of Tetrahymena pyriformis at concentrations up to 12.5 μg/ml, an inhibition in the synthesis of polar lipid.s was observed. Increasing concentrations of BHA decreased the percentage of Na‐2‐[ 14 C]‐acetate incorporated into lysophosphatidylcholine, 2‐aminoethyl‐phosphonolipids, and unknown polar lipid 1 while increasing the incorporation of radiolabel into phosphatidylethanolamine and unknown polar lipid II. BHA increased the cellular level of tetrahymanol and increased the molar ratio of tetrahymanol to lipid phosphorus. These data suggest that T. pyriformis alters its cellular lipid composition in response to perturbations caused by BHA.