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SEDATIVE ACTIVITY OF CELERY OIL CONSTITUENTS
Author(s) -
BJELDANES LEONARD F.,
KIM INSUK
Publication year - 1978
Publication title -
journal of food science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 150
eISSN - 1750-3841
pISSN - 0022-1147
DOI - 10.1111/j.1365-2621.1978.tb09755.x
Subject(s) - sedative , pentobarbital , depressant , sedation , barbiturate , long term potentiation , chemistry , ethanol , pharmacology , anesthesia , medicine , organic chemistry , biochemistry , receptor
The central depressant activities of 3, n‐butylphthalide and a new compound, sedanenolide, were studied in mice. While neither compound affects ethanol sedation, they exhibit similar activities in both prolonging pentobarbital narcosis by prior administration of the test compounds and in inducing sleep immediately following recovery from a prior treatment with barbiturate. Weak sedative activity is also shown to reside in both compounds without potentiation.