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TOXICOLOGICAL STUDY OF PATULIN IN MONKEYS
Author(s) -
GARZA H. C.,
SWANSON B. G.,
BRANEN A. L.
Publication year - 1977
Publication title -
journal of food science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 150
eISSN - 1750-3841
pISSN - 0022-1147
DOI - 10.1111/j.1365-2621.1977.tb14467.x
Subject(s) - patulin , dose , toxicity , mycotoxin , chemistry , transaminase , zoology , food science , biology , toxicology , biochemistry , pharmacology , organic chemistry , enzyme
Patulin 4‐hydroxy‐4H‐furo [3,2‐c] ‐pyran‐2(6H)‐one, a mycotoxin produced by certain Aspergillus and Penicillium species, has been found as a contaminant of apple products. Patulin has resulted in toxicological effects in mice and rats; however, little information is available on the oral toxicity of patulin to primates. In this study, pig‐tail monkeys ( Macaca nemestrina ) were given daily oral doses of patulin for a period of 4 wk. Four groups of two monkeys each were used. One group served as a control and the other groups were given daily dosages of either 5, 50 or 500 μg of patulin per kg of body weight. After 4 wk, the monkeys on 500 μg/kg were given daily dosages of 5 mg/kg for an additional two weeks. To administer appropriate dosages, patulin was dissolved in citric acid buffer and applied to sliced freeze‐dried bananas. Blood samples were taken weekly and hematology, serum protein elec‐trophoresis and levels of serum glutamate‐oxalacetate transaminase, alkaline phosphatase, blood urea nitrogen, cholesterol, protein, glucose, sodium and potassium were determined. No statistically significant changes were observed in these physiological parameters, with the exception of AP, which decreased as patulin dosages increased.