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SAFETY EVALUATION OF AN ENZYMATIC FISH PROTEIN HYDROLYSATE: 10‐MONTH FEEDING STUDY AND REPRODUCTION PERFORMANCE IN RATS
Author(s) -
BALLESTER D.,
YÁÑEZ E.,
BRUNSER O.,
STEKEL A.,
CHADUD P.,
CASTAÑO G.,
MONCKEBERG F.
Publication year - 1977
Publication title -
journal of food science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 150
eISSN - 1750-3841
pISSN - 0022-1147
DOI - 10.1111/j.1365-2621.1977.tb01510.x
Subject(s) - hydrolysate , hemoglobin , weanling , biology , hematocrit , litter , reproduction , zoology , casein , medicine , andrology , endocrinology , food science , biochemistry , ecology , hydrolysis
Weanling rats were fed an enzymatic fish protein hydrolysate (EFPH) at 10, 20 and 30% protein levels for 40 wk. Control animals were fed casein at 10% protein level. At 12, 24 and 40 wk, animals of each group were killed to determine hemoglobin cone, hematocrit, total red blood cells count and total and differential white cells count and for histological study. Experimental animals showed higher growth rate when compared to the controls. Hematological and histological studies showed no abnormalities. Fertility was studied in another group of animals and was found comparable to that of the controls. Litter sizes were similar and birth weights were normal in all groups except in the 10% EFPH, in which it was lower. Growth curves in this second generation were significantly higher in animals on 20 and 30% EFPH protein: at 15 days of age they reached the same weight as controls and 10% EFPH groups at 20 days. Results confirm the high quality and safety of this fish protein hydrolysate and open the possibility of using it to supplement the protein intake in developing countries.