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SYNERGISTIC TOXICITY OF FOOD ADDITIVES IN RATS FED A DIET LOW IN DIETARY FIBER
Author(s) -
ERSHOFF BENJAMIN H.
Publication year - 1976
Publication title -
journal of food science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 150
eISSN - 1750-3841
pISSN - 0022-1147
DOI - 10.1111/j.1365-2621.1976.tb00759.x
Subject(s) - food science , chemistry , dietary fiber , psyllium , food additive , nutrient , sodium , fiber , laxative , medicine , organic chemistry , constipation
Immature male rats were fed a purified, low‐fiber diet to which were added supplements of 2% sodium cyclamate, 2% FD&C Red No. 2 and 4% polyoxyethylene (20) sorbitan monostearate individually or in combination. Whereas supplements of any one of the three food additives indicated above had little if any deleterious effect, combined supplements of sodium cyclamate and FDK Red No. 2 resulted in a marked retardation in weight increment, an unthrifty appearance of the fur, alopecia and extensive diarrhea with watery and mushy stools Concurrent administration of all three food additives indicated above resulted in a further retardation in weight increment and death of all test animals within an experimental period of 14 days. The deleterious effects obtained on the latter diet could be largely counteracted by the concurrent administration of various dietary fiber‐containing materials. Blond psyllium seed powder was particularly potent in this regard. The protective factor or factors therein was distinct from any of the known nutrients and from cellulose per se.