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Heterotopic mineralization (ossification or calcification) in tendinopathy or following surgical tendon trauma
Author(s) -
O'Brien Etienne J. O.,
Frank Cyril B.,
Shrive Nigel G.,
Hallgrímsson Benedikt,
Hart David A.
Publication year - 2012
Publication title -
international journal of experimental pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.671
H-Index - 72
eISSN - 1365-2613
pISSN - 0959-9673
DOI - 10.1111/j.1365-2613.2012.00829.x
Subject(s) - heterotopic ossification , tendon , calcification , medicine , endochondral ossification , tendinopathy , ossification , surgery , anatomy , pathology , cartilage
Summary Heterotopic tendon mineralization (ossification or calcification), which may be a feature of tendinopathy or which may develop following surgical trauma (repair or graft harvest), has not received much attention. The purpose of this article is to review the prevalence, mechanisms and consequences of heterotopic tendon mineralization and to identify the gaps in our current understanding. We focus on endochondral heterotopic ossification and draw on knowledge of the mechanisms of this process in other tissues and conditions. Finally, we introduce a novel murine A chilles tendon needle injury model, which will enable us to further study the mechanisms and biomechanical consequences of tendon mineralization.

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