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MMP 7 is a target of the tumour‐associated antigen Ep CAM
Author(s) -
Denzel Sabine,
Mack Brigitte,
Eggert Carola,
Massoner Petra,
Stöcklein Nikolas,
Kemming Dirk,
Harréus Ulrich,
Gires Olivier
Publication year - 2012
Publication title -
international journal of experimental pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.671
H-Index - 72
eISSN - 1365-2613
pISSN - 0959-9673
DOI - 10.1111/j.1365-2613.2012.00826.x
Subject(s) - microbiology and biotechnology , matrix metalloproteinase , biology , signal transduction , chromosomal translocation , transmembrane protein , embryonic stem cell , proteolysis , biochemistry , gene , receptor , enzyme
Summary Epithelial cell adhesion molecule ( E p CAM ) is a single‐transmembrane protein, which is involved in numerous cellular processes including cell adhesion, proliferation, maintenance of stemness of embryonic cells and progenitors, migration and invasion. Activation of signal transduction by E p CAM is warranted by regulated intramembrane proteolysis and nuclear translocation of the intracellular domain E p ICD . Here, we describe matrix metalloproteinase 7 ( MMP 7) as a target gene of E p CAM signalling via E p ICD nuclear translocation. E p CAM and MMP 7 expression pattern and levels positively correlated in vitro and in vivo , and were strongly elevated in primary carcinomas of the head and neck area. Hence, MMP 7 is a novel target of E p CAM signalling.