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Lipid metabolism abnormalities in alcohol‐treated rabbits: a morphometric and haematologic study comparing high and low alcohol doses
Author(s) -
Ikemura Satoshi,
Yamamoto Takuaki,
Motomura Goro,
Iwasaki Kenyu,
Yamaguchi Ryosuke,
Zhao Garida,
Iwamoto Yukihide
Publication year - 2011
Publication title -
international journal of experimental pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.671
H-Index - 72
eISSN - 1365-2613
pISSN - 0959-9673
DOI - 10.1111/j.1365-2613.2011.00773.x
Subject(s) - alcohol , saline , bone marrow , medicine , ethanol , endocrinology , pathogenesis , lipid metabolism , biology , biochemistry
Summary The pathogenesis of alcohol‐induced osteonecrosis remains unclear. The purpose of the present study was to evaluate the morphological changes in bone marrow fat cells and the changes in the serum lipid levels in alcohol‐treated rabbits. Fifteen rabbits were randomly assigned into three groups: Four rabbits intragastrically received low‐dose alcohol (LDA) (15 ml/kg per day) containing 15% ethanol for 4 weeks, five rabbits received high‐dose alcohol (HDA) (30 ml/kg per day) for 4 weeks and six rabbits received physiologic saline for 4 weeks as a control group. Six weeks after the initial alcohol administration, all rabbits were sacrificed. The mean size of the bone marrow fat cells in rabbits treated with HDA was significantly larger than that in the control group ( P = 0.0001). Haematologically, the levels of triglycerides and free fatty acids in the rabbits treated with both low‐dose and HDA were significantly higher than those in the control group ( P = 0.001 for both comparisons). The results of this study are that there are lipid metabolism abnormalities, both morphologically and haematologically, after alcohol administration. Also these findings were more apparent in rabbits treated with HDA than those treated with LDA.