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Oxidative stress in obstructive nephropathy
Author(s) -
Dendooven Amélie,
Ishola Jr David A.,
Nguyen Tri Q.,
Van der Giezen Dionne M.,
Kok Robbert Jan,
Goldschmeding Roel,
Joles Jaap A.
Publication year - 2011
Publication title -
international journal of experimental pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.671
H-Index - 72
eISSN - 1365-2613
pISSN - 0959-9673
DOI - 10.1111/j.1365-2613.2010.00730.x
Subject(s) - pathophysiology , oxidative stress , fibrosis , medicine , inflammation , kidney , bioinformatics , pathology , biology
Summary Unilateral ureteric obstruction (UUO) is one of the most commonly applied rodent models to study the pathophysiology of renal fibrosis. This model reflects important aspects of inflammation and fibrosis that are prominent in human kidney diseases. In this review, we present an overview of the factors contributing to the pathophysiology of UUO, highlighting the role of oxidative stress.