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Disorders related with ageing in the gerbil female prostate (Skene’s paraurethral glands)
Author(s) -
Custodio Ana M. G.,
Santos Fernanda C. A.,
Campos Silvana G. P.,
Vilamaior Patricia Simone Leite,
Oliveira Sérgio M.,
Góes Rejane M.,
Taboga Sebastião R.
Publication year - 2010
Publication title -
international journal of experimental pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.671
H-Index - 72
eISSN - 1365-2613
pISSN - 0959-9673
DOI - 10.1111/j.1365-2613.2009.00685.x
Subject(s) - prostate , histopathology , prostatitis , intraepithelial neoplasia , prostate cancer , pathology , hyperplasia , prostate diseases , medicine , hormone , prostatic diseases , context (archaeology) , biology , cancer , paleontology
Summary The female organs, which are regulated by steroid hormones, are targets of studies especially those related to senescence. However, although the female prostate is an organ influenced by hormones and susceptible to lesions, there is still little information about its histopathology. Thus, given the morphophysiological similarity between the prostate in women and female gerbils, the present study aimed to identify the spontaneous histopathological changes in this rodent to provide contributions to the understanding of lesions that also affect the human female prostate. The structural, ultrastructural, immunohistochemical, morphometric‐stereological and serological aspects, as well as the quantification of the incidence, multiplicity and percentage of acini affected by different lesions were analyzed. Benign prostate lesions including hyperplasia, prostatitis, microcalculi and calculi; preneoplastic lesions like dysplasias; premalignant lesions, such as high grade prostatic intraepithelial neoplasia as well as malignant ones, specifically adenocarcinoma, were identified in the adult gland, but they were intensified during senescence, which is possibly due to the imbalance among steroid hormone levels. Although clinical attention focuses on other urogenital organs, the real condition of the histopathological injuries in the human female prostate should be considered. A serious preventive work regarding the female prostate could be applied in the gynaecological context in order to monitor the gland and avoid possible disturbances to women’s health and consequently provide better quality of life.