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Changes in serum concentration of antioxidants following treadmill exercise testing in patients with suspected ischaemic heart disease
Author(s) -
Ashmaig M.E.,
Starkey B.J.,
Ziada A.M.,
Amro A.,
Sobki S.,
Ferns G.A.A.
Publication year - 2001
Publication title -
international journal of experimental pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.671
H-Index - 72
eISSN - 1365-2613
pISSN - 0959-9673
DOI - 10.1111/j.1365-2613.2001.iep197.x
Subject(s) - medicine , vitamin e , treadmill , cholesterol , ischaemic heart disease , vitamin , ischemia , endocrinology , antioxidant , chemistry , biochemistry
Twenty‐four subjects with suspected ischaemic heart disease underwent a treadmill exercise stress test (TEST). Nine individuals developed ischaemia as defined by standard criteria. Total plasma antioxidant status (TPAS), and serum concentrations of vitamin E were measured pre‐TEST, and 0, 1, 2, 4, 8 and 24 h following the treadmill test. Mean serum vitamin E concentrations fell by 33% in the group as a whole (from 9.53 ± 0.92 mg/L pre‐TEST to 6.39 ± 1.06 mg/L immediately post stress test, P < 0.02) and rose to baseline over the subsequent 24 h. The levels of serum vitamin E fell by 34% in the group of patients who had a positive TEST, and 32% in those who did not develop ischaemia during the TEST. Serum cholesterol concentrations also fell significantly during the TEST. In the total group serum cholesterol fell by 6.5% ( P = 0.0052), and in the subgroup who were positive for ischaemia the fall in serum cholesterol was 10.3% ( P = 0.004). The reduction in serum cholesterol was 4.1% in the subgroup who did not develop ischaemia ( P > 0.05). Mean total plasma antioxidant status showed no significant temporal change for the group as a whole, although there was a nonsignificant decrease immediately post‐TEST in the ischaemic group and a slight rise at 8 h in the group negative for ischaemia.