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Combination of astaxanthin and fish oil supplementation alters antioxidant enzyme profile of dental pulp tissue
Author(s) -
Leite M. F.,
Lima A. M.,
Otton R.
Publication year - 2012
Publication title -
international endodontic journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.988
H-Index - 119
eISSN - 1365-2591
pISSN - 0143-2885
DOI - 10.1111/j.1365-2591.2012.02080.x
Subject(s) - antioxidant , glutathione reductase , superoxide dismutase , catalase , glutathione peroxidase , astaxanthin , fish oil , pulp (tooth) , oxidative stress , food science , chemistry , biochemistry , biology , medicine , dentistry , fish <actinopterygii> , carotenoid , fishery
Aim To evaluate the effect of administration of astaxanthin ( ASTA ) and fish oil ( FO ) on enzymatic antioxidant parameters of dental pulp tissue from healthy rats. Methodology Thirty‐two healthy W istar rats were divided into four groups: untreated control, ASTA ‐treated (1 mg kg −1 body weight), FO ‐treated (10 mg eicosapentaenoic acid per kg BW and 7 mg docosahexaenoic acid per kg BW ) and FO plus ASTA ‐treated. A prophylactic dose was administered in each group daily by gavage, 5 days a week, for 45 days. After treatment, the rats were killed and all incisor dental pulps were removed. Superoxide dismutase ( SOD ), catalase, glutathione ( GSH ) peroxidase and reductase activities were determined. Data were compared by anova and the T ukey's post‐test ( P < 0.05). Results Treatment with FO , ASTA and FO plus ASTA caused a reduction in SOD and GSH reductase activities in dental pulp tissue compared to untreated control rats ( P < 0.05). ASTA partially stimulated catalase activity. Conclusions The preventive administration of ASTA and FO changed the enzymatic antioxidant system of dental pulp tissue, possibly by controlling oxidative stress.