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Multiple osteolytic lesions of intraosseous adenoid cystic carcinoma in the mandible mimicking apical periodontitis
Author(s) -
Grimm M.,
Henopp T.,
Hoefert S.,
Schaefer F.,
Kluba S.,
Krimmel M.,
Reinert S.
Publication year - 2012
Publication title -
international endodontic journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.988
H-Index - 119
eISSN - 1365-2591
pISSN - 0143-2885
DOI - 10.1111/j.1365-2591.2012.02079.x
Subject(s) - adenoid cystic carcinoma , medicine , mandible (arthropod mouthpart) , periodontitis , carcinoma , dentistry , pathology , biology , botany , genus
Grimm M, Henopp T, Hoefert S, Schaefer F, Kluba S, Krimmel M, Reinert S. Multiple osteolytic lesions of intraosseous adenoid cystic carcinoma in the mandible mimicking apical periodontitis. International Endodontic Journal . Aim Adenoid cystic carcinoma ( ACC ) is a relatively rare epithelial tumour of the salivary glands in the maxillofacial region. About 40–60% of the patients develop distant metastases, which have been documented most commonly in the lung but also in brain, bone, liver, thyroid, spleen and pancreatic gland. Summary A 55‐year‐old women with intraosseous ACC in the mandible mimicking apical periodontitis following curative resection and radiotherapy is presented. Three years later, multiple lung metastases were observed followed by chemotherapy. Five years after curative resection, the patient presented simultaneously with new expansive soft tissue in the pancreas and mammary gland as well as in the kidney found to be metastatic ACC . No case has been reported to date on the manifestation of distant metastases of intraosseous ACC in the breast and the kidney as described by these observations. Metastatic mammary gland ACC stained positive for epithelial growth factor receptor ( EGFR ) but was negative for HER ‐2/neu and Cyclooxygenase‐2 ( COX ‐2) expression.