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Interleukin 1 gene cluster SNPs (rs1800587, rs1143634) influences post‐orthodontic root resorption in endodontic and their contralateral vital control teeth differently
Author(s) -
IglesiasLinares A.,
YañezVico R. M.,
Ballesta S.,
OrtizAriza E.,
MendozaMendoza A.,
Perea E.,
SolanoReina E.
Publication year - 2012
Publication title -
international endodontic journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.988
H-Index - 119
eISSN - 1365-2591
pISSN - 0143-2885
DOI - 10.1111/j.1365-2591.2012.02065.x
Subject(s) - medicine , dentistry , single nucleotide polymorphism , odds ratio , confidence interval , orthodontics , genotype , gene , genetics , biology
Iglesias‐Linares A, Yañez‐Vico RM, Ballesta S, Ortiz‐Ariza E, Mendoza‐Mendoza A, Perea E, Solano‐Reina E. Interleukin 1 gene cluster SNPs (rs1800587, rs1143634) influences post‐orthodontic root resorption in endodontic and their contralateral vital control teeth differently. International Endodontic Journal , 45 , 1018–1026, 2012. Abstract Aim To investigate whether the genetic variants of the interleukin‐1 gene cluster ( IL1 ) are associated with a possible genetically induced variability in post‐orthodontic external apical root resorption (EARR) in root filled teeth and their control counterparts with vital pulps. Methodology One hundred and forty‐six maxillary premolars were evaluated radiographically following orthodontic treatment. Genetic screening was performed on orthodontic patients for two single‐nucleotide polymorphisms (SNPs: rs1800587 and rs1143634) in the IL1 gene cluster. Subjects were divided into two groups according to the presence or absence of radiographic post‐orthodontic EARR (>2 mm) in root filled teeth and their controls with vital pulps. Logistic regression analysis was performed to obtain an adjusted estimation between EARR and IL1 polymorphisms. Allelic frequencies, genotype distributions, and adjusted odds ratio (OR), at 95% confidence interval, were also calculated. Results Whilst no clear statistical association was found for gene variations in IL1A , a sound association was found in the comparative analysis of subjects homozygous [2/2(TT)] for the IL1B gene, which resulted in a two times increased risk of suffering post‐orthodontic EARR in root filled teeth [OR, 2.032 ( P = 0.031); CI,1.99–14.77] when compared with their controls with vital pulps. There was, however, a shared predisposition to EARR in controls with vital pulps and root filled teeth of subjects homozygous for allele 1 [OR, 5.05 ( P = 0.002)] and [OR, 2.77 ( P = 0.037)], respectively. Conclusions Genetic variations in the interleukin‐1β gene (rs1143634) predispose root filled teeth to EARR for matched pairs secondary to orthodontic treatment in a different way from their control teeth with vital pulps in subjects homozygous for allele 2 [2/2(TT)].