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Mesenchymal stem cells derived from dental tissues
Author(s) -
RodríguezLozano F. J.,
Bueno C.,
Insausti C. L.,
Meseguer L.,
Ramírez M. C.,
Blanquer M.,
Marín N.,
Martínez S.,
Moraleda J. M.
Publication year - 2011
Publication title -
international endodontic journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.988
H-Index - 119
eISSN - 1365-2591
pISSN - 0143-2885
DOI - 10.1111/j.1365-2591.2011.01877.x
Subject(s) - stem cell , stem cell transplantation for articular cartilage repair , mesenchymal stem cell , dental follicle , dental pulp stem cells , periodontal ligament stem cells , clinical uses of mesenchymal stem cells , microbiology and biotechnology , biology , adult stem cell , regenerative medicine , progenitor cell , regeneration (biology) , embryonic stem cell , pathology , medicine , alkaline phosphatase , biochemistry , gene , enzyme
Rodríguez‐Lozano FJ, Bueno C, Insausti CL, Meseguer L, Ramírez MC, Blanquer M, Marín N, Martínez S, Moraleda JM. Mesenchymal stem cells derived from dental tissues. International Endodontic Journal , 44 , 800–806, 2011. Abstract Regeneration of tissues occurs naturally due to the existence of stem cells with the capacity to self‐regenerate and differentiate; however, regenerative capacity decreases with age, and in many cases, regeneration is not sufficient to repair the damage produced by degenerative, ischaemic, inflammatory, or tumour‐based diseases. In the last decade, advances have been made in the understanding of stem cells, the genes that control the alternative fates of quiescence and differentiation, and the niches that provide specific signals that modulate cell fate decisions. Embryonic stem‐cell research is shedding light on the secrets of development. Adult stem cells (AS cells) are available from several sources. Bone marrow and connective tissue have been used in preliminary clinical trials for regenerative therapy. Recently, several types of AS cells have been isolated from teeth, including dental pulp stem cells, stem cells from human exfoliated deciduous teeth, periodontal ligament stem cells, dental follicle progenitor stem cells and stem cells from apical papilla. Preliminary data suggest that these cells have the capacity to differentiate into osteoblasts, adipocytes, chondrocytes and neural cells. If confirmed, these data would support the use of these cells, which are easily obtained from extracted teeth, in dental therapies, including in regenerative endodontics, providing a new therapeutic modality.