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In vivo astaxanthin treatment partially prevents antioxidant alterations in dental pulp from alloxan‐induced diabetic rats
Author(s) -
Leite M. F.,
De Lima A.,
Massuyama M. M.,
Otton R.
Publication year - 2010
Publication title -
international endodontic journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.988
H-Index - 119
eISSN - 1365-2591
pISSN - 0143-2885
DOI - 10.1111/j.1365-2591.2010.01707.x
Subject(s) - alloxan , astaxanthin , in vivo , antioxidant , pulp (tooth) , diabetes mellitus , pharmacology , medicine , chemistry , dentistry , biochemistry , endocrinology , biology , microbiology and biotechnology , carotenoid
Leite MF, de Lima A, Massuyama MM, Otton R.In vivo astaxanthin treatment partially prevents antioxidant alterations in dental pulp from alloxan‐induced diabetic rats. International Endodontic Journal , 43 , 959–967, 2010. Abstract Aim To evaluate the effect of astaxanthin on antioxidant parameters of dental pulp from diabetic rats. The hypothesis tested was that supplementation of diabetic rats with astaxanthin might eliminate, or at least attenuate, the defect in their antioxidative status. Methodology Wistar rats ( n = 32) were divided into four groups: untreated control, treated control, untreated diabetic and treated diabetic rats. A prophylactic dose of astaxanthin (20 mg kg −1 body weight) was administered daily by gavage for 30 days. On day 23, diabetes was induced by injection of alloxan (60 mg kg −1 body weight). After 7 days of diabetes induction, the rats were killed, and pulp tissue from incisor teeth removed. Superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx) and reductase activities were determined. Data were compared by anova and the Newman–Keuls test ( P < 0.05). Results Diabetes caused a reduction in SOD, GPx and reductase activity in dental pulp tissue. Astaxanthin had no effect on SOD and catalase activities; however, it stimulated GPx in control and diabetic rats. Conclusions Diabetes altered the antioxidant system in dental pulp tissue; astaxanthin partially improved the diabetic complications.