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Assessment of a gel‐type chelating preparation containing 1‐hydroxyethylidene‐1, 1‐bisphosphonate
Author(s) -
Girard S.,
Paqué F.,
Badertscher M.,
Sener B.,
Zehnder M.
Publication year - 2005
Publication title -
international endodontic journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.988
H-Index - 119
eISSN - 1365-2591
pISSN - 0143-2885
DOI - 10.1111/j.1365-2591.2005.01021.x
Subject(s) - ethylenediaminetetraacetic acid , smear layer , chelation , sodium hypochlorite , nuclear chemistry , iodometry , chemistry , aqueous solution , calcium , chromatography , titration , citric acid , hypochlorite , root canal , dentistry , inorganic chemistry , medicine , biochemistry , organic chemistry
Aim To test an aqueous gel containing 1‐hydroxyethylidene‐1, 1‐bisphosphonate (HEBP) regarding its interactions with sodium hypochlorite, its calcium binding capacity, and its potential in preventing the formation of a smear layer when used in conjunction with rotary root canal preparation. Methodology The experimental aqueous gel consisted of (w/v) 2% alginate, 3% aerosil, 10% Tween 80 and 18% HEBP. Interactions of gel components with hypochlorite were assessed using iodometric titration and monochromatic ultraviolet spectrometry. Two commercial paste‐type chelators containing ethylenediaminetetraacetic acid (EDTA) and peroxide (RC‐Prep and Glyde) served as controls. Calcium‐binding capacities were measured in mixtures with a Ca 2+ standard solution buffered at pH 10 using a calcium‐selective measuring chain. Finally, root canals of 16 extracted single‐rooted premolars per group were instrumented using ProFile instruments dipped in the experimental gel, RC‐Prep, or nothing. Additionally, canals were rinsed with 10 mL of a 1% NaOCl solution during/after preparation. Smear scores in instrumented teeth were monitored using scanning electron microscopy. Results None of the experimental gel components showed short‐term interactions with hypochlorite, whilst EDTA, peroxide, RC‐Prep and Glyde immediately reduced the hypochlorite in solution. The experimental gel chelated 30 mg Ca 2+ g −1 , compared with 16 mg Ca 2+ g −1 and 11 mg Ca 2+ g −1 chelated by RC‐Prep and Glyde respectively. Smear scores obtained with the experimental gel were significantly ( P < 0.05) lower than with RC‐Prep in coronal and middle root thirds, whilst no differences were observed in apical root thirds. Conclusions Under the conditions of this study, an HEBP gel appeared advantageous over currently available products.